Diagnosis of non‐alcoholic fatty liver disease/non‐alcoholic steatohepatitis: Non‐invasive tests are enough


Non‐alcoholic fatty liver disease is a major cause of liver disease worldwide and the most common liver disorder in Western countries, affecting around 25% of the general population. Fibrosis is the major long‐term histological prognostic criteria of this disease. Liver biopsy cannot be realistically performed in such a huge population and, moreover, has well‐known limitations (invasiveness, rare but potentially life‐threatening complications and sampling variability). Over the past decade, there has been a growing interest in alternative novel strategies for the non‐invasive evaluation of fibrosis. These tests rely on two different but complementary approaches: either measuring the levels of serum biomarkers, or liver stiffness, using ultrasound‐based elastography techniques. In non‐alcoholic fatty liver disease patients, transient elastography, FIB‐4 and the non‐alcoholic fatty liver disease fibrosis score are the best validated tests, with summary area under the ROC curve values for diagnosing severe fibrosis‐cirrhosis of 0.88, 0.84 and 0.84 respectively. They can also identify the subgroup of non‐alcoholic fatty liver disease patients at high risk of developing liver‐related complications and death. As a result, non‐invasive tests are now widely used in routine clinical practice and included in national and international guidelines. The next step is the use of non‐invasive tests as first‐line tools for screening non‐alcoholic fatty liver disease in the general population to identify patients who should be referred to specialized centres.


fibrosis, liver stiffness, nonalcoholic fatty liver disease, non‐invasive, serum biomarkers, transient elastography


About Speaker




City: Paris

Institution: University of Paris-VII (Hôpital Beaujon, Clichy)

Contact: laurent.castera@bjn.aphp.fr

Biography of Laurent CASTERA

Laurent Castera (MD, PhD) is Professor of Hepatology at the University of Paris-VII (Department of Hepatology, Hopital Beaujon, Clichy, France) and Visiting Professor of Medicine in University College of London (Institute of Liver and Digestive Health, Royal Free Hospital London, UK). He received his Medical degree from the University of Paris-VI and his PhD from the University of Paris-XII. His research interests focus on non-invasive methods for liver fibrosis assessment, NAFLD and viral hepatitis. He has published more than 180 papers in international peer reviewed journals and also serves on the editorial boards of the Journal of Hepatology, Gut and Liver International. He has been the chairman of the first international guidelines on the use of non-invasive tests (EASL-ALEH Clinical Practice Guidelines J Hepatol 2015). He has served on the Scientific Committee of the United European Gastroenterology (UEG) from 2011 to 2013 and on the Council of UEG since 2017. He has been a member of the European Association for the Study of the Liver (EASL) Governing Board from 2012 to 2013, EASL Vice Secretary from 2013 to 2015 and EASL Secretary General from 2015 to 2017.

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